[Zoledronate regulates osteoclast differentiation and bone resorption in high glucose through p38 MAPK pathway].

CONCLUSIONS: High glucose inhibits osteoclast differentiation and bone resorption. ZOL inhibits osteoclast differentiation and bone resorption in high-glucose conditions by regulating p38 MAPK pathway, which can be a new pathway for ZOL to regulate diabetic osteoporosis.
PMID: 33118518 [PubMed - in process]

Source: Journal of Southern Medical University - October 30, 2020 Category: Universities & Medical Training Authors: Lin Y, Gu Y, Zuo G, Jia S, Liang Y, Qi M, Dong W Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research