Day-to-day variability of [ 68 Ga]Ga-PSMA-11 accumulation in primary prostate cancer: effects on tracer uptake and visual interpretation

ConclusionResults of test-retest [68Ga]Ga-PSMA-11 PET/CT scans in a 4-week interval show that [68Ga]Ga-PSMA-11 uptake is repeatable, with a clinical irrelevant variation in tumor and physiological distribution. Based on the presented repeatable uptake, [68Ga]Ga-PSMA-11 PET/CT scans can potentially be used for disease surveillance and therapy response monitoring. Changes in uptake larger than the RC are therefore likely to reflect actual biological changes in PSMA expression.Trial registration NL8263 at Trialregister.nl retrospectively registered on 03-01-2020.https://www.trialregister.nl/trial/8263
Source: EJNMMI Research - Category: Radiology Source Type: research