Presentations and Outcomes of Central Nervous System TB in a UK Cohort: The high burden of neurological morbidity

Central nervous system TB (CNS-TB) represents one of the most serious clinical manifestations of Mycobacterium tuberculosis (MTB) infection. There are two main patterns of disease presentation: (i) tuberculous meningitis (TBM) and (ii) intracranial tuberculous mass lesion(s) (TBML). Although CNS-TB only accounts for about 1% of TB cases,1 it contributes disproportionately to morbidity and mortality. Pathologically, CNS-TB arises from haematogenous seeding of M. tuberculosis to the brain following pulmonary infection.

Source: Journal of Infection - October 30, 2020 Category: Infectious Diseases Authors: Clare Logan, Claire Mullender, Miriam Mirfenderesky, Nicholas Feasey, Catherine Cosgrove, Peter Riley, Angela Houston, Tom Harrison, Tihana Bicanic, Phil Rich, Paul Hart, S íle F Molloy, Derek C. Macallan Source Type: research