Ultrastructural and proapoptotic-like effects of kaempferol in Giardia duodenalis trophozoites and bioinformatics prediction of its potential protein target.

CONCLUSIONS: KPF exerted a proapoptotic effect on G. duodenalis trophozoites involving partial interruption of DNA synthesis without oxidative stress or structure damage to chromatin and cytoskeletal structures. GdAldRed is a likely target underlying its antigiardial activity. PMID: 33111756 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/33111756?dopt=Abstract

Source: Memorias do Instituto Oswaldo Cruz - October 30, 2020 Category: Infectious Diseases Authors: Argüello-García R, Calzada F, García-Hernández N, Chávez-Munguía B, Velázquez-Domínguez JA Tags: Mem Inst Oswaldo Cruz Source Type: research