Treatment of Epilepsy Associated with Periventricular Nodular Heterotopia

This article reviews recent studies that help understanding the epileptogenicity and potential therapeutic options in PNH.Recent FindingsNew noninvasive diagnostic and intracerebral EEG analytic tools demonstrated that cortical hyperexcitability and aberrant connectivity (between nodules and cortices and among nodules) are likely mechanisms causing epilepsy in most patients. The deeply seated PNH, if epileptogenic, are ideal target for stereotactic ablative techniques, which offer concomitant ablation of multiple regions with relatively satisfactory seizure outcome.SummaryAdvance in diagnostic and analytic tools have enhanced our understanding of the complex epileptogenicity in PNH. Development in stereotactic ablative techniques now offers promising therapeutic options for these patients.
Source: Current Neurology and Neuroscience Reports - Category: Neuroscience Source Type: research