Ins and Outs: Perspectives of Inpatient Prescribing for Sacubitril/Valsartan.

Ins and Outs: Perspectives of Inpatient Prescribing for Sacubitril/Valsartan.
Ann Pharmacother. 2020 Oct 28;:1060028020964923
Authors: Gillette M, Bozkurt B
Abstract
Heart failure is a major public health concern with a rising prevalence and significant financial detriment. Although sacubitril/valsartan was shown to reduce the risk of death and hospitalization from heart failure in a contemporary cohort, it continues to remain substantially underutilized. A recent article in the Annals highlights the evidence behind inpatient initiation of sacubitril/valsartan. We provide further considerations and summarize the evidence for inpatient initiation of other guideline directed medical therapies. Overall, there is a need to improve methods to identify ideal populations and increase utilization in those who may benefit from sacubitril/valsartan. Further research is also needed to identify the risks versus benefits among underrepresented populations (i.e., advanced heart failure, heart failure with preserved ejection fraction, in conjunction with other contemporary evidence-based therapies that can lower blood pressure, etc.).
PMID: 33111533 [PubMed - as supplied by publisher]

Source: The Annals of Pharmacotherapy - October 28, 2020 Category: Drugs & Pharmacology Authors: Gillette M, Bozkurt B Tags: Ann Pharmacother Source Type: research