Seizure burden and neurodevelopmental outcome in newborns with hypoxic-ischemic encephalopathy treated with therapeutic hypothermia: A single center observational study

Hypoxic ischemic encephalopathy (HIE) occurs in 1 –8 newborns per 1000 live births and it is the most common cause of seizures in term neonates. [1] Many studies in asphyxiated neonates before the advent of therapeutic hypothermia [TH] have shown a relationship between clinical and/or electrographic seizures, especially status epilepticus, and ab normal outcome. [2] Due to the overlapping between the ischemic hypoxic damage and the injury resulting from seizures activity, it is still difficult to establish the impact of seizures in the exacerbation of brain damage and in the worsening outcome of asphyxiated newborns [3].

Source: Seizure: European Journal of Epilepsy - October 29, 2020 Category: Neurology Authors: Claudia Basti, Eugenia Maranella, Nicola Cimini, Alessia Catalucci, Simona Ciccarelli, Marianna Del Torto, Luisa Di Luca, Cecilia Di Natale, Arianna Mareri, Valentina Nardi, Veronica Pannone, Sandra Di Fabio Source Type: research