Sex- and region-biased depletion of microglia/macrophages attenuates CLN1 disease in mice

The neuronal ceroid lipofuscinoses (CLN diseases) are fatal lysosomal storage diseases causing neurodegeneration in the CNS. We have previously shown that neuroinflammation comprising innate and adaptive immun...

Source: Journal of Neuroinflammation - October 28, 2020 Category: Neurology Authors: Kristina Berve, Brian L. West, Rudolf Martini and Janos Groh Tags: Research Source Type: research