Evaluating Responses to Gluten Challenge: A Randomized, Double-Blind, 2-Dose Gluten Challenge Trial

Gluten challenge is used to diagnose celiac disease (CeD) and for clinical research. Sustained gluten exposure reliably induces histological changes but is burdensome. We investigated the relative abilities of multiple biomarkers to assess disease activity induced by two gluten doses, and aimed to identify biomarkers to supplement or replace histology.

Source: Gastroenterology - October 29, 2020 Category: Gastroenterology Authors: Maureen M. Leonard, Jocelyn A. Silvester, Daniel Leffler, Alessio Fasano, Ciar án P. Kelly, Suzanne K. Lewis, Jeffrey D. Goldsmith, Elliot Greenblatt, William W. Kwok, William J. McAuliffe, Kevin Galinsky, Jenifer Siegelman, I-Ting Chow, John A. Wagner, Source Type: research