Mitochondrial DNA drives noncanonical inflammation activation via cGAS –STING signaling pathway in retinal microvascular endothelial cells

Pathological stimuli cause mitochondrial damage and leakage of mitochondrial DNA (mtDNA) into the cytosol, as demonstrated in many cell types. The cytosolic mtDNA then drives the activation of noninfectious in...

Source: Cell Communication and Signaling - October 28, 2020 Category: Molecular Biology Authors: Yue Guo, Ruiping Gu, Dekang Gan, Fangyuan Hu, Gang Li and Gezhi Xu Tags: Research Source Type: research