Functional Analysis of RELN S2486G Mutation and its Contribution to Pathogenesis of Ankylosing Spondylitis.

CONCLUSION: The S2486G mutation in RELN can alter inflammatory and, to some extent, osteogenesis pathways mediated by reduced secretion of reelin and also reduced expression of the PLA2G7 gene.
PMID: 33107310 [PubMed - in process]

Source: Archives of Iranian Medicine - October 1, 2020 Category: Middle East Health Authors: Esmaeilzadeh-Gharehdaghi E, Razmara E, Bitaraf A, Jamshidi A, Mahmoudi M, Garshasbi M Tags: Arch Iran Med Source Type: research