A comprehensive overview of colon cancer- a grim reaper of the 21st century.

A comprehensive overview of colon cancer- a grim reaper of the 21st century. Curr Med Chem. 2020 Oct 26;: Authors: Kumar R, Harilal S, Carradori S, Mathew B Abstract A few decades ago, the incidence of colorectal cancer (CRC) was low and is now the fourth in the list of deadly cancers producing nearly a million deaths annually. A population that is aging along with risk factors such as smoking, obesity, sedentary lifestyle with little or no physical activity, and non-healthy food habits of developed countries can increase the risk of colorectal cancer. The balance in gut microbiota and the metabolites produced during bacterial fermentation within the host play a significant role in regulating intestinal diseases as well as colorectal cancer development. Recent progress in the understanding of illness resulted in multiple treatment options such as surgery, radiation, and chemotherapy including targeted therapy and multitherapies. The treatment plan for CRC depends on location, stage and grade of the cancer as well as genomic biomarker tests. Despite all the advancements made in the genetic and molecular aspects of the disease, the knowledge seems inadequate as the drug action as well as the wide variation in drug response did not appear strongly correlated with the individual molecular and genetic characteristics which suggests the requirement of comprehensive molecular understanding of this complex heterogeneous disease. Furthermore,...
Source: Current Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Med Chem Source Type: research