PD-1 Signaling Promotes Tumor-Infiltrating Myeloid-Derived Suppressor Cells and Gastric Tumorigenesis in Mice

Immune checkpoint inhibitors have limited efficacy in many tumors. We investigated mechanisms of tumor resistance to inhibitors of programmed cell death 1 (PDCD1, also called PD1) in mice with gastric cancer, and the role of its ligand, PDL1.

Source: Gastroenterology - October 28, 2020 Category: Gastroenterology Authors: Woosook Kim, Timothy H. Chu, Henrik Nienh üser, Zhengyu Jiang, Armando Del Portillo, Helen E. Remotti, Ruth A. White, Yoku Hayakawa, Hiroyuki Tomita, James G. Fox, Charles G. Drake, Timothy C. Wang Source Type: research