Targeting of δ-catenin to postsynaptic sites through interaction with the Shank3 N-terminus

ConclusionsOur data show that the interaction between Shank3 N-terminus and δ-catenin is required for the postsynaptic targeting of δ-catenin. Failure of proper targeting of δ-catenin to postsynaptic sites may contribute to the pathogenesis of autism spectrum disorder.

Source: Molecular Autism - October 28, 2020 Category: Molecular Biology Source Type: research