It is Possible to Achieve Tablets with Good Tabletability from Solid Dispersions - the Case of the High Dose Drug Gemfibrozil.

CONCLUSION: SDs proved to be effective for simultaneously improving tabletability and dissolution profile of gemfibrozil. Tablets containing gemfibrozil-HPMC-SD and croscarmellose sodium as disintegrating agent showed improved drug release and good mechanical strength, demonstrating the potential of HPMC-based SDs to simultaneously overcome the poor dissolution and tabletability properties of this drug.
PMID: 33100203 [PubMed - as supplied by publisher]

Source: Current Drug Delivery - October 23, 2020 Category: Drugs & Pharmacology Authors: Bigogno ER, Soares L, Mews MHR, Zétola M, Bazzo GC, Stulzer HK, Pezzini BR Tags: Curr Drug Deliv Source Type: research