Regeneration Defects in Yap and Taz Mutant Mouse Livers are Caused by Bile Duct Disruption and Cholestasis

The Hippo pathway and its downstream effectors YAP and TAZ (YAP/TAZ) are heralded as important regulators of organ growth and regeneration. However, different studies provided contradictory conclusions about their role during regeneration of different organs ranging from promoting proliferation to inhibiting it. Here, we resolve the function of YAP/TAZ during regeneration of the liver, where Hippo ’s role in growth control has been studied most intensely.

Source: Gastroenterology - October 27, 2020 Category: Gastroenterology Authors: Elisabeth Verboven, Iv án M. Moya, Leticia Sansores-Garcia, Jun Xie, Hanne Hillen, Weronika Kowalczyk, Gerlanda Vella, Stefaan Verhulst, Stéphanie A. Castaldo, Ana Algueró-Nadal, Lucia Romanelli, Cristina Mercader-Celma, Natália A. Souza, Soheil Sohei Source Type: research