Fine-tuning lipid metabolism by targeting mitochondria-associated Acetyl-CoA-Carboxylase 2 in BRAFV600E papillary thyroid carcinoma.

CONCLUSIONS: These findings suggest a potential link between BRAFV600E and lipid metabolism regulation in PTC. BRAFV600E down-regulates ACC2 levels, which deregulates de novo lipid synthesis, FAO due to OCR, and ECAR rates. ShACC2 may contribute to vemurafenib resistance and increased tumor growth. ACC2 rescue may represent a novel molecular strategy for overcoming resistance to BRAFV600E inhibitors in refractory PTC. PMID: 33107403 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research