Limitations and limits and of vascularized composite allotransplantations: can we reach the holy grail?

Limitations and limits and of vascularized composite allotransplantations: can we reach the holy grail? Curr Opin Organ Transplant. 2020 Dec;25(6):609-614 Authors: Grajek M, Bula D, Zeman M, Maciejewski A Abstract PURPOSE OF REVIEW: In recent times, vascularized composite allotransplantation (VCA) have been gaining more attention and applications. Currently, VCA are at the highest level of the reconstruction pyramid, and thus the effects expected after them are intended to outweigh what the 'classical' reconstructive surgery can offer us, including even the most advanced microsurgical techniques. RECENT FINDINGS: Over 40 patients have received a partial or full-face transplant. Others have received penis, uterus, larynx, abdominal wall, and lower extremity transplants. Each type of VCA has its own problems and limitations. However, resolving the limits defined by immunosuppression and improved donor selection would revolutionize all of them. SUMMARY: Defining the limits and limitations of given procedures will not only allow for better preparation of transplant teams but will also help in determining the direction of future research. PMID: 33105202 [PubMed - in process]
Source: Current Opinion in Organ Transplantation - Category: Transplant Surgery Authors: Tags: Curr Opin Organ Transplant Source Type: research