Persistently elevated mTORC1-S6 kinase 1 disrupts DARPP-32-dependent D1 dopamine receptor signaling and behaviors

The serine-threonine kinase mammalian target of rapamycin complex 1 (mTORC1) is essential for normal cell function but is aberrantly activated in brain in both genetic-developmental and sporadic diseases and is associated with a spectrum of neuropsychiatric symptoms. The underlying molecular mechanisms of cognitive and neuropsychiatric symptoms remain controversial.

Source: Biological Psychiatry - October 27, 2020 Category: Psychiatry Authors: Raozhou Lin, Lisa N. Learman, Chan-Hyun Na, Santosh Renuse, Kevin T. Chen, Po Yu Chen, Gum-Hwa Lee, Bo Xiao, Susan M. Resnick, Juan C. Troncoso, Karen K. Szumlinski, David J. Linden, Joo-Min Park, Alena Savonenko, Akhilesh Pandey, Paul F. Worley Tags: Priority Communication Source Type: research