Egr2 regulation in T cells is mediated through IFN γ/STAT1 and IL-6/STAT3 signalling pathway.
In this study, we analysed the Egr2 expression mechanism in CD4 T cells under antigen stimulation. We found that Egr2 expression is regulated by different cytokines including IL-2 and IL-4, which increased Egr2 induction in activated T cells. However, inflammatory cytokines, including INFγ and IL-6, suppressed Egr2 expression through STAT1 and STAT3 signalling pathway respectively, highlighting a mechanism for tolergenic immune response on T cells.
PMID: 33099163 [PubMed - as supplied by publisher]
Source: Pathology, Research and Practice - Category: Pathology Authors: Taefehshokr N, Miao T, Symonds ALJ, Wang P, Li S Tags: Pathol Res Pract Source Type: research