Molecules, Vol. 25, Pages 4931: New Fluorene Derivatives from Dendrobium gibsonii and Their α-Glucosidase Inhibitory Activity

Molecules, Vol. 25, Pages 4931: New Fluorene Derivatives from Dendrobium gibsonii and Their α-Glucosidase Inhibitory Activity
Molecules doi: 10.3390/molecules25214931
Authors:
May Thazin Thant
Nutputsorn Chatsumpun
Wanwimon Mekboonsonglarp
Boonchoo Sritularak
Kittisak Likhitwitayawuid

Two new compounds, dihydrodengibsinin (1) and dendrogibsol (2), were isolated from the whole plant of Dendrobium gibsonii, together with seven known compounds (3–9). The structures of the new compounds were elucidated by their spectroscopic data. All these isolates were evaluated for their α-glucosidase inhibitory activities. Dendrogibsol (2) and lusianthridin (7) showed strong α-glucosidase inhibitory activity when compared with acarbose. An enzyme kinetic study revealed that dendrogibsol (2) is a noncompetitive inhibitor of α-glucosidase.

Source: Molecules - October 25, 2020 Category: Chemistry Authors: May Thazin Thant Nutputsorn Chatsumpun Wanwimon Mekboonsonglarp Boonchoo Sritularak Kittisak Likhitwitayawuid Tags: Article Source Type: research