Minocycline as adjunctive treatment for major depressive disorder: Pooled data from two randomized controlled trials.

CONCLUSION: The improvement of depressive symptoms, anxiety severity and functional status is promising and suggests that minocycline has potential as an adjunctive treatment for major depressive disorder. However, further studies are warranted to confirm therapeutic effects of minocycline in major depressive disorder.
TRIAL REGISTRATIONS: NCT02263872, registered October 2014, and ACTRN12612000283875, registered March 2012.
PMID: 33092404 [PubMed - as supplied by publisher]

Source: The Australian and New Zealand Journal of Psychiatry - October 22, 2020 Category: Psychiatry Authors: Zazula R, Husain MI, Mohebbi M, Walker AJ, Chaudhry IB, Khoso AB, Ashton MM, Agustini B, Husain N, Deakin J, Young AH, Berk M, Kanchanatawan B, Ng CH, Maes M, Berk L, Singh AB, Malhi GS, Dean OM Tags: Aust N Z J Psychiatry Source Type: research