Polygenic prediction of PTSD trajectories in 9/11 responders.

CONCLUSIONS: Psychiatric PRSs prospectively predicted WTC-related PTSD lifetime diagnosis, average symptom severity, and 18-year trajectory in responders to 9/11 disaster. Jointly, PRSs were more predictive of subsequent PTSD than the exposure severity. In the future, PRSs may help identify at-risk responders who might benefit from targeted prevention approaches.
PMID: 33092657 [PubMed - as supplied by publisher]

Source: Psychological Medicine - October 23, 2020 Category: Psychiatry Authors: Waszczuk MA, Docherty AR, Shabalin AA, Miao J, Yang X, Kuan PF, Bromet E, Kotov R, Luft BJ Tags: Psychol Med Source Type: research