Molecules, Vol. 25, Pages 4927: Modeling of the Production of Lipid Microparticles Using PGSS ® Technique
Molecules, Vol. 25, Pages 4927: Modeling of the Production of Lipid Microparticles Using PGSS® Technique
Molecules doi: 10.3390/molecules25214927
Authors:
López-Iglesias
López
Fernández
Landin
García-González
Solid lipid microparticles (SLMPs) are attractive carriers as delivery systems as they are stable, easy to manufacture and can provide controlled release of bioactive agents and increase their efficacy and/or safety. Particles from Gas-Saturated Solutions (PGSS®) technique is a solvent-free technology to produce SLMPs, which involves the use of supercritical CO2 (scCO2) at mild pressures and temperatures for the melting of lipids and atomization into particles. The determination of the key processing variables is crucial in PGSS® technique to obtain reliable and reproducible microparticles, therefore the modelling of SLMPs production process and variables control are of great interest to obtain quality therapeutic systems. In this work, the melting point depression of a commercial lipid (glyceryl monostearate, GMS) under compressed CO2 was studied using view cell experiments. Based on an unconstrained D-optimal design for three variables (nozzle diameter, temperature and pressure), SLMPs were produced using the PGSS® technique. The yield of production was registered and the particles characterized in terms of particle size distribution. Variable modeling was carried out using artificial neural networks and fu...
Source: Molecules - Category: Chemistry Authors: L ópez-Iglesias L ópez Fern ández Landin Garc ía-González Tags: Article Source Type: research