Severe Malarial Thrombocytopenia: A Risk Factor for Mortality in Papua, Indonesia

Background The significance of thrombocytopenia to the morbidity and mortality of malaria is poorly defined. We compared the platelet counts and clinical correlates of patients with and those without malaria in southern Papua, Indonesia. Methods Data were collated on patients presenting to a referral hospital between April 2004 and December 2012. Results Platelet measurements were available in 215 479 patients (23.4%), 66 421 (30.8%) of whom had clinical malaria. Patients with Plasmodium falciparum monoinfection had the lowest platelet counts and greatest risk of severe thrombocytopenia (platelet count,
Source: The Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: PARASITES Source Type: research

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This study evaluated the haematological profile of adult individuals infected with the malaria parasite. Methods: A retrospective study was conducted using archived data of malaria positive cases from January 2017 to March 15, 2019. Data retrieved included subjects' demographics, malaria parasite count, malaria parasite species, and full blood count parameters. A total of 236 malaria positive subjects were included in the study. Results: The study showed that more females were infected with the malaria parasite than males (69.07% and 30.93%, respectively). A total of 87.3% of the study population were infected with...
Source: Advances in Hematology - Category: Hematology Tags: Adv Hematol Source Type: research
Abstract Malaria is a parasitic infection of global importance but has a high prevalence in the developing countries. Renal failure is a common complication of severe Plasmodium falciparum malaria and has been reported in up to 40% of all cases. Acute kidney injury (AKI), however, is not commonly associated with Plasmodium vivax infection. In those patients who develop AKI following P. vivax infection, the cause is commonly attributed to mixed undiagnosed falciparum infection or coexistent sepsis, dehydration, or hypotension. Infrequently, an association of P. vivax infection with thrombotic microangiopathy (TMA) ...
Source: Saudi Journal of Kidney Diseases and Transplantation - Category: Urology & Nephrology Authors: Tags: Saudi J Kidney Dis Transpl Source Type: research
CONCLUSIONS: This study suggests that parasite load together with malarial anemia, rather than alveolar leakage, might contribute to shortened survival in PbNK65-infected Vwf-/- mice. VWF deficiency is associated with early reticulocytosis following PbNK65 infection, which potentially explains the increase in parasite load. This article is protected by copyright. All rights reserved. PMID: 31099973 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - Category: Hematology Authors: Tags: J Thromb Haemost Source Type: research
Conclusion and Future Directions The ECM model has produced a wealth of information on CM pathogenesis in mice with the aim to find an adjunctive therapy for HCM but its validity has been questioned. However, several investigators have provided a critical and evidence-based defense of this model (17, 128–131) and from knowledge gained from it, numerous laboratories have tested preclinical therapeutic interventions. Many have demonstrated efficacy at blocking the development of ECM but disappointingly, in a majority of cases, this was only found when administered before or early post infection and prior to the onset ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Conclusions Nucleoside hydrolases are vital enzymes for the replication of Leishmania, conserved phylogenetic marker of the genus and strong-specific immunogens. We demonstrated that NH36 is an excellent target for chemotherapy of visceral leishmaniasis. Searching for the most immunogenic fraction of promastigotes of Leishmania we described the FML antigen of L. (L.) donovani, that has as its main component, the NH36 Nucleoside hydrolase. We developed second–generation vaccines with the FML and the NH36 native antigens, and with the NH36 recombinant protein. In addition, we obtained a third generation vaccine based ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
​BY GREGORY TAYLOR, DO; DAWN ZELENKA-JOSHOWITZ, DO; &ANDREW TAECKER, DOA 34-year-old man presented with intermittent fever and body aches for 10 days. He had been visiting family in India, and the symptoms began when he returned home. His fever had been as high as 104°F, and he was experiencing nausea, two episodes of bilious emesis, body aches, nonspecific abdominal pain, and multiple episodes of watery, nonbloody diarrhea.He said he knew of no tuberculosis exposure or ill contacts, and he was current on his routine influenza and hepatitis A vaccines. His temperature was 101.4°F (he had taken acetaminophen t...
Source: The Case Files - Category: Emergency Medicine Tags: Blog Posts Source Type: research
DISCUSSION : Further studies need to be continued in order to contribute to the clinical characterization of malaria in the Department and Management interventions. Adjustments to format are recommended to strengthen analysis and decision-making. PMID: 30183888 [PubMed - in process]
Source: Revista de Salud Publica - Category: International Medicine & Public Health Tags: Rev Salud Publica (Bogota) Source Type: research
This study revealed that unregulated interaction of the parasite with host immune response has important consequences in disease progression and thus relevant for therapeutic and vaccine development.
Source: Egyptian Journal of Basic and Applied Sciences - Category: Science Source Type: research
AbstractBackgroundMalaria and human immunodeficiency virus are the two most devastating global health problems causing more than two million deaths each year. Hematological abnormalities such as anemia, thrombocytopenia and leucopenia are the common complications in malaria and HIV co-infected individuals. The aim of this study was to determine the effect of malaria infection on hematological profiles of people living with HIV attending Gambella Hospital ART clinic, Southwestern Ethiopia.ObjectiveTo determine the effect of malaria infection on hematological profiles of people living with HIV attending Gambella Hospital ART...
Source: BMC Hematology - Category: Hematology Source Type: research
Conclusion Clinical association of vivax malaria with TMA leading to HUS is novel and suggests parasite related severe endothelial injury. Future studies are needed to demonstrate interaction of parasite with endothelium and factors related to it.
Source: Pediatric Infectious Disease - Category: Pediatrics Source Type: research
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