Epithelial TLR4 signaling activates DUOX2 to induce microbiota-driven tumorigenesis

Chronic colonic inflammation leads to dysplasia and cancer in patients with inflammatory bowel disease (IBD). We have described the critical role of innate immune signaling via toll-like receptor 4 (TLR4) in the pathogenesis of dysplasia and cancer. In the current study, we interrogate the intersection of TLR4 signaling, epithelial redox activity, and the microbiota in colitis-associated neoplasia.

Source: Gastroenterology - October 23, 2020 Category: Gastroenterology Authors: Juan F. Burgue ño, Julia Fritsch, Eddy E. Gonzalez, Kevin S. Landau, Ana M. Santander, Irina Fernández, Hajar Hazime, Julie M. Davies, Rebeca Santaolalla, Matthew C. Phillips, Sophia Diaz, Rishu Dheer, Nivis Brito, Judith Pignac-Kobinger, Ester Fernánd Source Type: research