III. Detecting treatment effects in clinical trials with different indices of pain intensity derived from ecological momentary assessment

Pain intensity is the primary outcome in most clinical trials of pain disorders.14 Although a substantial body of research has been devoted to determining reliable and valid methods of self-reported pain assessment,25 an important question is whether and how the information obtained from pain intensity measures could be improved to enhance detection of treatment effects.23,24,47,48,53 The overall amount of pain (typically conceptualized as the average pain level over a day or week) has served as the most common pain intensity outcome in many clinical trials.
Source: The Journal of Pain - Category: Materials Science Authors: Tags: Original Reports Source Type: research