Molecules, Vol. 25, Pages 4914: Isolation and Characterization of Phenylpropanoid and Lignan Compounds from Peperomia pellucida [L.] Kunth with Estrogenic Activities

Molecules, Vol. 25, Pages 4914: Isolation and Characterization of Phenylpropanoid and Lignan Compounds from Peperomia pellucida [L.] Kunth with Estrogenic Activities
Molecules doi: 10.3390/molecules25214914
Authors:
I Gusti Agung Ayu Kartika
In Jae Bang
Catur Riani
Muhamad Insanu
Jong Hwan Kwak
Kyu Hyuck Chung
I Ketut Adnyana

Extracts of Peperomia pellucida [L.] Kunth have previously been demonstrated to have in vivo estrogenic-like effects, thereby functioning as an anti-osteoporotic agent. However, the compounds responsible for these effects have not yet been determined. Therefore, the aim of this study is to isolate and elucidate potential compounds with estrogenic activity. The structures of the isolated compounds were identified using 1D 1H and 13C-NMR and confirmed by 2D FT-NMR. The estrogenic activity was evaluated using the E-SCREEN assay, and a molecular docking study was performed to predict the binding affinity of the isolated compounds to estrogen receptors. In this experiment, we successfully isolated three phenylpropanoids and two lignan derivatives, namely, 6-allyl-5-methoxy-1,3-benzodioxol-4-ol (1), pachypostaudin B (2), pellucidin A (3), dillapiole (4), and apiol (5). Among these compounds, the isolation of 1 and 2 from P. pellucida is reported for the first time in this study. Activity assays clearly showed that the ethyl acetate extract and its fractions, subfractions, and isolated compounds exerted estrogenic activity. Methanol fraction...

Source: Molecules - October 23, 2020 Category: Chemistry Authors: I Gusti Agung Ayu Kartika In Jae Bang Catur Riani Muhamad Insanu Jong Hwan Kwak Kyu Hyuck Chung I Ketut Adnyana Tags: Article Source Type: research