Complete RH and Kell matching related to low alloimmunisation risk in sickle cell disease: prevalence and risk factors of alloimmunisation in a Spanish Tertiary Care National Reference Centre.

We report a low alloimmunisation prevalence (8.4%) related to a high grade of RH-Kell matching. However, deviation from 100% translates into alloimmunisation, with >50% of alloantibodies corresponding to RH-Kell. Alloimmunisation risk increases with transfusion burden, particularly during acute complications, and in patients with a higher number of VOC, probably reflecting underlying inflammation and disease severity. Further studies will be needed to elucidate additional risk factors and help prevent alloimmunisation in these patients.
PMID: 33085598 [PubMed - as supplied by publisher]

Source: Blood Transfusion - October 14, 2020 Category: Hematology Authors: Regalado-Artamendi I, Pérez-Corral AM, García-Morín M, Cela E, Beléndez C, Bardón-Cancho EJ, Pérez-Rus G, Pérez-Sánchez I, Pascual C, Monsalvo S, Falero C, Díez-Martín JL, Anguita J Tags: Blood Transfus Source Type: research