Electrochemical C-H Amidation of Heteroarenes with N-Alkyl Sulfonamides in Aqueous Medium.
Electrochemical C-H Amidation of Heteroarenes with N-Alkyl Sulfonamides in Aqueous Medium.
Chemistry. 2020 Oct 21;:
Authors: Zhang Y, Lin Z, Ackermann L
Abstract
The construction of C-N bonds by free radical reactions represents a powerful synthetic approach for direct C-H amidations of arenes or heteroarenes. Developing efficient and more environmentally-friendly synthetic methods for C-H amidation reactions remains highly desirable. Herein, metal-free electrochemical oxidative dehydrogenative C-H amidations of heteroarenes with N -alkylsulfonamides have been accomplished. The catalyst- and chemical oxidant-free C-H amidation features an ample scope, and employes electricity as the green and sole oxidant. A variety of heteroarenes, including indoles, pyrroles, benzofuran and benzothiophene, thereby underwent this C(sp 2 )-H nitrogenation. Cyclic voltammetry studies and control experiments provided evidence for nitrogen-centered radicals being directly generated under metal-free electrocatalysis.
PMID: 33085807 [PubMed - as supplied by publisher]
Source: Chemistry - Category: Chemistry Authors: Zhang Y, Lin Z, Ackermann L Tags: Chemistry Source Type: research