A straightforward synthesis of polyketides via ester dienolate Matteson homologation.

A straightforward synthesis of polyketides via ester dienolate Matteson homologation.
Chemistry. 2020 Oct 22;:
Authors: Andler O, Kazmaier U
Abstract
Application of ester dienolates as nucleophiles in Matteson homologations allows the stereoselective synthesis of highly substituted α,β-unsaturated δ-hydroxy carboxyl acids, structural motifs widespread found in polyketide natural products. The protocol is rather flexible and permits the introduction of substituents and functionalities also at those positions which are not accessible by the commonly used aldol reaction. Therefore, this ester dienolate Matteson approach is an intersting alternative to the "classical" polyketide syntheses.
PMID: 33089903 [PubMed - as supplied by publisher]

Source: Chemistry - October 22, 2020 Category: Chemistry Authors: Andler O, Kazmaier U Tags: Chemistry Source Type: research