Seizure rescue medications for out-of-hospital use in children

For the past two decades, rectal diazepam (Diastat) has been the sole US Food and Drug Administration (FDA)-approved medication for treatment of bouts of seizures in the out-of-hospital setting for patients with epilepsy. Clonazepam has also been used frequently off-label for acute, repetitive seizures, as well as other indications. In the past year, the FDA has approved two new formulations as seizure rescue medications: intranasal midazolam (Nayzilam), and intranasal diazepam (Valtoco). Seizure rescue medications are rapidly acting antiepileptic drugs that help to stop a seizure quickly before it progresses to a medical emergency, such as status epilepticus.
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: Medical Progress Source Type: research