Night Watch on the Titanic: Detecting Early Signs of Epileptogenesis in Alzheimer Disease.

Night Watch on the Titanic: Detecting Early Signs of Epileptogenesis in Alzheimer Disease.
Epilepsy Curr. 2020 Oct 20;:1535759720964775
Authors: Lam AD, Noebels J
Abstract
Aberrant cortical network excitability is an inextricable feature of Alzheimer disease (AD) that can negatively impact memory and accelerate cognitive decline. Surface electroencephalogram spikes and intracranial recordings of nocturnal silent seizures in human AD, coupled with the abnormal neural synchrony that precedes development of behavioral seizures in mouse AD models, build the case for epileptogenesis as an early therapeutic target for AD. Since most individuals with AD do not develop overt seizures, leveraging functional biomarkers of epilepsy risk to stratify a heterogeneous AD patient population for treatment is research priority for successful clinical trial design. Who will benefit from antiseizure interventions, which one, and when should it begin?
PMID: 33081517 [PubMed - as supplied by publisher]

Source: Epilepsy Curr - October 20, 2020 Category: Neurology Authors: Lam AD, Noebels J Tags: Epilepsy Curr Source Type: research