Diuretics and Risk of Lower Extremity Amputation Amongst Patients with Insulin-treated Type 2 Diabetes - Exploring the mechanism of possible Sodium Glucose co-transporter 2 inhibitor induced risk of lower extremity amputations.

CONCLUSION: While diuretic use appeared to be associated with an increased risk of LEA among insulin-treated T2D patients, this association is marginally significant after controlling for confounding factors by cohort matching. These results suggest that volume depletion may be a factor in increasing the risk of LEA amongst high-risk T2D patients, but the strength of this association is weak when adjusted for all other risk factors. Thus, patient selection is crucial when determining the safe use of agents that induce volume depletion in high risk patients with T2D. PMID: 33085525 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research