A Selective Sulfide Oxidation catalyzed by Heterogeneous Artificial Enzymes Iron@NikA.

A Selective Sulfide Oxidation catalyzed by Heterogeneous Artificial Enzymes Iron@NikA.
Chemistry. 2020 Oct 20;:
Authors: Menage S, Lopez S, Marchi-Delapierre C, Cavazza C
Abstract
Performing a heterogeneous catalysis with proteins is still a challenge. Here, we demonstrate the importance of cross-linked crystals for sulfoxide oxidation by an artificial enzyme. The biohybrid consists of the insertion of an iron complex into a NikA protein crystal. The heterogeneous catalysts displays a better efficiency-with higher reaction kinetics, a better stability and expand the substrate scope compared to its solution counterpart. Designing crystalline artificial enzymes represents a good alternative to soluble or supported enzymes for the future of synthetic biology.
PMID: 33079395 [PubMed - as supplied by publisher]

Source: Chemistry - October 20, 2020 Category: Chemistry Authors: Menage S, Lopez S, Marchi-Delapierre C, Cavazza C Tags: Chemistry Source Type: research