Laminar analysis of the cortical T1/T2-weighted ratio at 7T

Conclusions Laminar analysis of T1w/T2w ratio mapping confirms the presence of cortical damage in MS and shows a variable expression of intracortical damage according to the disease phenotype. Although in the relapsing-remitting stage, only the subpial layer appears susceptible to damage, in progressive patients, widespread cortical abnormalities can be observed, not only, as described before, with regard to myelin/iron concentration but, possibly, to other microstructural features.

http://nn.neurology.org/cgi/content/short/7/6/e900?rss=1

Source: Neurology Neuroimmunology and Neuroinflammation - October 21, 2020 Category: Neurology Authors: Petracca, M., El Mendili, M. M., Moro, M., Cocozza, S., Podranski, K., Fleysher, L., Inglese, M. Tags: MRI, Multiple sclerosis Article Source Type: research