Impaired metabolic brain networks associated with neurotransmission systems in the a-synuclein spectrum

While the involvement of multiple neurotransmitter systems in α-synucleinopathies is reported, a comprehensive study on their metabolic connectivity reconfiguration in the preclinical and clinical disease-spectrum is lacking. We aimed to investigate shared and disease-specific neural vulnerabilities of the nigro-striato-cortical dopaminergic, noradrenergic an d cholinergic networks within the α-synuclein-spectrum, by means of a metabolic connectivity approach.

Source: Parkinsonism and Related Disorders - October 21, 2020 Category: Neurology Authors: Giulia Carli, Silvia Paola Caminiti, Arianna Sala, Andrea Galbiati, Andrea Pilotto, Luigi Ferini-Strambi, Alessandro Padovani, Daniela Perani Source Type: research