CD40L-stimulated B cells for  ex vivo expansion of polyspecific nonhuman primate regulatory T cells for translational studies.

CONCLUSIONS: We developed an approach for the expansion of highly suppressive MCM polyspecific Tregs through the use of a combination of CD40L-engeniered B cells with the potential to be translated to clinical studies. To our knowledge, this is the first report that uses a pool of MHC-mismatched CD40L-sBc to create polyspecific Tregs suitable for use in deceased-donor transplants. PMID: 33058141 [PubMed - as supplied by publisher]
Source: Clinical and Developmental Immunology - Category: Allergy & Immunology Authors: Tags: Clin Exp Immunol Source Type: research