Long-Term Follow-up of High-Dose Chemotherapy with Autologous Stem Cell Transplantation in Children and Young Adults with Metastatic or Relapsed Ewing Sarcoma: A Single-Institution Experience

Ewing sarcoma (EWS) arises in bone and soft tissue and most commonly occurs in adolescents and young adults. With current therapy, the survival rate ranges from 75% to 80% for patients with localized disease at diagnosis [1,2]. Unfortunately, patients with metastatic disease at diagnosis have a much poorer outcome when treated with standard chemotherapy with a 3-year survival rate range between 10% and 30% [1-3]. Further, the survival rate for patients with recurrent disease also remains poor despite aggressive treatment; 5-year overall survival (OS) for patients with recurrent or progressive disease after first-line therapy ranges between 0% and 20% [3-6].
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research