The association between Candida infection and ankylosing spondylitis: a population-based matched cohort study.

CONCLUSIONS: A risk of AS was found after Candida infection, and year of follow up acts as an effect modifier between the Candida infection and risk of AS. Key message: What is already known on this subject? Links between spondyloarthritis and fungal infections have been found in animal studies before. What does this study add? Our study demonstrated that Candida infection is an independent risk factor for developing ankylosing spondylitis in terms of gender, age, and relevant variables and comorbidities. A risk of ankylosing spondylitis was found after Candida infection, and year of follow up acts as an effect modifier between the Candida infection and risk of AS. Clinicians should be aware of possible Candida infection in managing patients with ankylosing spondylitis. Implications: Clinicians must pay greater attention to patients with newly diagnosed Candida infection. Specifically, they should conduct tests for ankylosing spondylitis. Further research is needed to examine if and how treatment of Candida infection alleviates symptoms of AS. PMID: 33066709 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research