Involvement of Cxcl12a/Cxcr4b Chemokine System in Mediating the Stimulatory Effect of Embryonic Ethanol Exposure on Neuronal Density in Zebrafish Hypothalamus.

CONCLUSIONS: These results provide clear evidence that EtOH's stimulatory effects at low-moderate doses on the number of hypothalamic neurons early in development are mediated, in part, by increased transcription and intracellular activation of this chemokine system, likely due to autocrine signaling of Cxcl12a at its Cxcr4b receptor within the neurons. PMID: 33067812 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/33067812?dopt=Abstract

Source: Alcoholism, Clinical and Experimental Research - October 17, 2020 Category: Addiction Authors: Collier AD, Khalizova N, Chang GQ, Min S, Campbell S, Gulati G, Leibowitz SF Tags: Alcohol Clin Exp Res Source Type: research

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