GSE124688 Blood RNA signature predicts recent tuberculosis exposure in mice

Contributors : Russell C Ault ; Colwyn A Headley ; Alexander E Hare ; Bridget J Carruthers ; Asuncion Mejias ; Joanne TurnerSeries Type : Expression profiling by arrayOrganism : Mus musculusKnowing when a person was infected with Mycobacterium tuberculosis (M.tb) is critical as recent infection is the strongest clinical risk factor for progression to TB disease in immunocompetent individuals. However, time since M.tb infection is very difficult to determine in routine clinical practice. We determined whether gene expression patterns in blood RNA correlate with time since M.tb infection or exposure to develop a biomarker for recent exposure. As proof of concept, we found an RNA signature that accurately discriminated early and late time periods after experimental infection in mice.

Source: GEO: Gene Expression Omnibus - October 20, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research