Fecal transplantation and butyrate improve neuropathic pain, modify immune cell profile, and gene expression in the PNS of obese mice [Physiology]

Obesity affects over 2 billion people worldwide and is accompanied by peripheral neuropathy (PN) and an associated poorer quality of life. Despite high prevalence, the molecular mechanisms underlying the painful manifestations of PN are poorly understood, and therapies are restricted to use of painkillers or other drugs that do not...

Source: Proceedings of the National Academy of Sciences - October 20, 2020 Category: Science Authors: Raiza R. Bonomo, Tyler M. Cook, Chaitanya K. Gavini, Chelsea R. White, Jacob R. Jones, Elisa Bovo, Aleksey V. Zima, Isabelle A. Brown, Lara R. Dugas, Eleonora Zakharian, Gregory Aubert, Francis Alonzo III, Nigel A. Calcutt, Virginie Mansuy-Aubert Tags: Biological Sciences Source Type: research