Journey to the Center of the Cell: Tracing the Path of AAV Transduction.

Journey to the Center of the Cell: Tracing the Path of AAV Transduction. Trends Mol Med. 2020 Oct 15;: Authors: Dhungel BP, Bailey CG, Rasko JEJ Abstract As adeno-associated virus (AAV)-based gene therapies are being increasingly approved for use in humans, it is important that we understand vector-host interactions in detail. With the advances in genome-wide genetic screening tools, a clear picture of AAV-host interactions is beginning to emerge. Understanding these interactions can provide insights into the viral life cycle. Accordingly, novel strategies to circumvent the current limitations of AAV-based vectors may be explored. Here, we summarize our current understanding of the various stages in the journey of the vector from the cell surface to the nucleus and contextualize the roles of recently identified host factors. PMID: 33071047 [PubMed - as supplied by publisher]
Source: Trends in Molecular Medicine - Category: Molecular Biology Authors: Tags: Trends Mol Med Source Type: research