Reduction of cardiac dose using respiratory-gated MR-linac plans for gastro-esophageal junction cancer

Treatment of locally advanced adenocarcinoma of the gastroesophageal junction (GEJ) with chemoradiation may be associated with high rates of symptomatic cardiac toxicity. Large margins are typically required to ensure coverage of GEJ tumors with free-breathing volumetric modulated arc therapy (VMAT) radiotherapy. The purpose of this study is to determine whether treatment with tighter margins enabled by maximum-inhalation breath hold (MIBH)-gated intensity modulated radiation therapy (IMRT) on an integrated MRI-linear accelerator system (MR-linac) can decrease radiation doses to the heart and cardiac substructures.

Source: Medical Dosimetry - October 20, 2020 Category: Radiology Authors: Sangjune Laurence Lee, Peter Mahler, Stephanie Olson, Jacob S. Witt, Hima Bindu Musunuru, Victoria Rajamanickam, Michael F. Bassetti, Poonam Yadav Source Type: research