The regulatory role of exosomal CagA and microRNAs derived from H. pylori -related gastric cancer cells on signaling pathways related to cancer development: a bioinformatics aspect

AbstractExosomes are small vesicles outside the membrane, which are secreted by healthy, cancerous, and bacterial infected cells. These worthy vesicles carry shared information between adjacent cells and cause cell-cell communication. Bacteria can also secrete vesicles similar to exosomes called outer membrane vesicles (OMVs). The OMVs, also called quasi-exosomes due to its similarity to exosomes, are bacterial extracellular membrane vesicles that are secreted to enhance the pathogenicity of the bacteria. The continued secretion of exosome by cells and quasi-exosome by bacteria in gastric cancer played a vital role in cancer progression to metastasis and acute cancer state. In gastric cancer associated withHelicobacter pylori infection, both cancerous and immune cells secretion are involved. Exosomes and quasi-exosomes interact with each other to overcome cancer or worsen it. Cancer cells, through the involvement of T lymphocytes and macrophages, make these cells to secrete. Exosomes stimulate the immune system and improve gastric cancer. Exosomes containing CagA, miR155, MET, and GGT factors play an important role in gastric cancer. The regulatory role of some of these factors such as microRNAs and CagA are evaluated by enrichment analysis. KEGG pathway analysis illustrated the most significant pathway of upregulated gene in gastric cancer patient with inflammation history ofH. pylori. Functional annotation analysis ofH. pylori-related gastric sample highlighted the cluster ...
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research