A hydrogel-based optical fibre fluorescent pH sensor for observing lung tumor tissue acidity.

A hydrogel-based optical fibre fluorescent pH sensor for observing lung tumor tissue acidity.
Anal Chim Acta. 2020 Oct 16;1134:136-143
Authors: Gong J, Tanner MG, Venkateswaran S, Stone JM, Zhang Y, Bradley M
Abstract
Technologies for measuring physiological parameters in vivo offer the possibility of the detection of disease and its progression due to the resulting changes in tissue pH, or temperature, etc.. Here, a compact hydrogel-based optical fibre pH sensor was fabricated, in which polymer microarrays were utilized for the high-throughput discovery of an optimal matrix for pH indicator immobilization. The fabricated hydrogel-based probe responded rapidly to pH changes and demonstrated a good linear correlation within the physiological pH range (from 5.5 to 8.0) with a precision of 0.10 pH units. This miniature probe was validated by measuring pH across a whole ovine lung and allowed discrimination of tumorous and normal tissue, thus offering the potential for the rapid and accurate observation of tissue pH changes.
PMID: 33059859 [PubMed - in process]

Source: Analytica Chimica Acta - October 16, 2020 Category: Chemistry Authors: Gong J, Tanner MG, Venkateswaran S, Stone JM, Zhang Y, Bradley M Tags: Anal Chim Acta Source Type: research