Role of nuclear factor of activated T cells 2 (NFATc2) in allergic asthma

ConclusionsIn addition to NFATc1 and NIP45, NFATc2 was found upregulated in asthma. Moreover, NFATc1 mRNA correlated with lymphocytes both in control and asthma, and NFATC1 and NFATc2 mRNA showed a direct correlation with eosinophils in controls but not in asthma, indicating that NFATc1 is associated with lymphocytes and not eosinophils in asthma.Clinical SignificanceTargeting NFATc2 in T lymphocytes might ameliorate the allergic phenotype in asthmatic subjects.

Source: Immunity, Inflammation and Disease - October 20, 2020 Category: Allergy & Immunology Authors: Marielena Jakobi, Alexander Kiefer, Hooman Mirzakhani, Manfred Rauh, Theodor Zimmermann, Paraskevi Xepapadaki, Barbara Stanic, Mubeccel Akdis, Nikolaos G. Papadopoulos, Benjamin A. Raby, Scott T. Weiss, Susetta Finotto Tags: ORIGINAL RESEARCH Source Type: research