A nanoprobe based on gated mesoporous silica nanoparticles for the selective and sensitive detection of benzene metabolite t,t-muconic acid in urine.

A nanoprobe based on gated mesoporous silica nanoparticles for the selective and sensitive detection of benzene metabolite t,t-muconic acid in urine. Chemistry. 2020 Oct 16;: Authors: Domínguez M, Blandez JF, Lozano-Torres B, de la Torre C, Licchelli M, Mangano C, Amendola V, Sancenón F, Martínez-Máñez R Abstract Benzene is a highly toxic aromatic hydrocarbon. Inhaling benzene can cause dizziness, vertigo, headaches, aplasia, mutations and, in the most extreme cases, cancer. Trans, trans-muconic acid (t,t-MA) is one of the metabolization products of benzene.  Although different analytical methods have been reported for the determination of t,t-MA, these are often expensive, require trained personnel, are not suitable for on-site measurements, and use hazardous organic solvents. For these reasons, the development of reliable, selective and sensitive methods for rapid and in situ detection of t, t-MA are of importance. Addressing this challenge, a nanodevice for the selective and sensitive quantification of t,t-MA in urine is reported. The nanodevice used is achieved using mesoporous silica nanoparticles loaded with a dye reporter and capped with a dicopper(II) azacryptand. Pore opening and payload release is induced rapidly (10 min) and selectively with t,t-MA in urine, using a simple fluorimeter without sample pretreatment. PMID: 33064343 [PubMed - as supplied by publisher]
Source: Chemistry - Category: Chemistry Authors: Tags: Chemistry Source Type: research