The relation between tau pathology and granulovacuolar degeneration of neurons.

The relation between tau pathology and granulovacuolar degeneration of neurons.
Neurobiol Dis. 2020 Oct 15;:105138
Authors: Puladi B, Dinekov M, Arzberger T, Taubert M, Köhler C
Abstract
Neurofibrillary tangles arising from aggregated microtubule-associated protein tau occur in aged brains and are hallmarks of neurodegenerative diseases. A subset of neurons containing aggregated tau displays granulovacuolar degeneration (GVD) that is characterized by membrane-bound cytoplasmic vacuoles, each containing an electron-dense granule (GVB). Tau pathology induces GVBs in experimental models, but GVD does not generally follow tau pathology in the human brain. The entorhinal cortex, DRN, and LC are among the regions that display pathological changes of tau earliest, whereas neurons with GVBs occur first in the hippocampus and have been found in oral raphe nuclei only at the most advanced GVD stage. To date, there is no detailed report about neurons with GVD in aminergic nuclei. We studied the relation between tau pathology and GVD in field CA1 of the hippocampus, entorhinal cortex, dorsal (DRN) and median (MRN) raphe nucleus, and locus coeruleus from elderly subjects with Braak & Braak stages of tau pathology ranging from 0 to VI. Tau pathology and GVBs were visualized by means of immunolabeling and quantified. Percentages of neurons containing GVBs were significantly related to percentages of AT8-positive neurons in the regions examined...

Source: Neurobiology of Disease - October 15, 2020 Category: Neurology Authors: Puladi B, Dinekov M, Arzberger T, Taubert M, Köhler C Tags: Neurobiol Dis Source Type: research